abstract：:An investigation was made into the effects of hyperammonemia on the metabolism of brain serotonin (5-HT). The animal model used was the sparse fur (spf) mouse, which possesses an inborn error of the urea cycle, i.e. an abnormal form of ornithine transcarbamylase. Several indoles were measured in brain and plasma using...

journal_title：Neurochemistry international

authors： Chaouloff F,Laude D,Mignot E,Kamoun P,Elghozi JL

更新日期：1985-01-01 00:00:00

abstract：:Intrastriatal kainic acid (2 ?g/?l) administration gave rise to significant increase in activities of glutamine synthetase and arginase along with a significant decrease in the activity of glutaminase in the lesioned striatal tissue 7 days after the administration of kainic acid. The increase in the activity of glutam...

journal_title：Neurochemistry international

authors： Nadiger HA,Rani Marcus S,Chandrakala MV,Sadasivudu B

更新日期：1985-01-01 00:00:00

abstract：:Intrauterine growth retardation induced by ligation of the uterine vessels in pregnant rats on the 5th day before delivery was associated with brain and body weights of hypotrophic offspring significantly lower than those of pair-aged control rats, even after 6 weeks of postnatal rearing under normal conditions. In vi...

journal_title：Neurochemistry international

authors： Chanez C,Flexor MA,Hamon M

更新日期：1985-01-01 00:00:00

abstract：:Neosurugatoxin, a neurotoxin isolated from the Japanese ivory mollusc (Babylonia japonica ) is a nicotinic antagonist with a specificity towards ganglionic nicotinic receptors. At low concentration (5 x 10(?8) M) neosurugatoxin inhibited the release of [(3)H]dopamine evoked by 1,1-dimethyl-4-phenylpiperazinium (DMPP) ...

journal_title：Neurochemistry international

authors： Rapier C,Harrison R,Lunt GG,Wonnacott S

更新日期：1985-01-01 00:00:00

abstract：:The concentrations of histamine reported vary considerably from species to species. The present studies sought to determine if blood sampling techniques were at least in part responsible for this large variability. Since plasma catecholamines are influenced by the stress associated with blood sampling, these biogenic ...

journal_title：Neurochemistry international

authors： Head RJ,Jarrott B,Libys J,Robinson RL,Stitzel RE,Zavisca F

更新日期：1985-01-01 00:00:00

abstract：:An intraocular injection of [(3)H]proline was used to label rabbit retinal ganglion cells including components subjected to axonal transport. Degradation of rapidly axonally transported labelled proteins was estimated in an in vitro system using homogenates of the nerve terminal regions. The energy requirements of thi...

journal_title：Neurochemistry international

authors： Gustavsson S,Karlsson JO

更新日期：1985-01-01 00:00:00

abstract：:The effect of subcutaneous injections of saline (0.9% NaCl, 10-40 ?l/g b. wt) to 5- and 20-day old rats on the concentrations of tyrosine (Tyr) and tryptophan (Trp) in the serum and the brain and on the levels of biogenic amines and their metabolites in the developing brain at 6 h p.i. is described. At day 5 the conce...

journal_title：Neurochemistry international

authors： Huether G,Thoemke F,Sprotte U,Steinhaus U,Neuhoff V

更新日期：1985-01-01 00:00:00

abstract：:Acyl-CoA synthetase activity was investigated in membrane fractions from normal and Trembler mouse sciatic nerves. Stearoyl-CoA synthesis in the Trembler assays was always about twice that observed in the control experiments under various conditions of CoA and ATP concentrations. In experiments using varying concentra...

journal_title：Neurochemistry international

authors： Boiron F,Heape AM,Cassagne C

更新日期：1985-01-01 00:00:00

abstract：:The transmitter dopamine and the protein acetylcholinesterase are released within the substantia nigra from the dendrites of nigrostriatal neurons. These phenomena do not correspond to the familiar events involved in information transfer at the classic axons synapse. It is possible that both dopamine and acetylcholine...

journal_title：Neurochemistry international

authors： Greenfield SA

更新日期：1985-01-01 00:00:00

abstract：:The parenchyma of the anterior pituitary gland is constituted of distinct specialized glandular cell types, some of them being able to secrete two, or more, genetically related hormones. The synthesis and the release of each hormone is a discontinuous process controlled by a variety of chemical signals of hypothalamic...

journal_title：Neurochemistry international

authors： Gourdji D

更新日期：1985-01-01 00:00:00

abstract：:Precise anatomical distribution of 5HT1 binding sites has been investigated in the nuclei raphe dorsalis, raphe centralis and locus caeruleus of the rat brain. An original pattern of distribution was observed in the raphe nuclei, closely correlated to the already known distribution of 5HT containing elements. This pat...

journal_title：Neurochemistry international

authors： Weissmann-Nanopoulos D,Mach E,Magre J,Demassey Y,Pujol JF

更新日期：1985-01-01 00:00:00

abstract：:The distribution of substance P in the colon of piebald lethal (s(1)/s(1)) mice was studied by radioimmunoassay and immunohistochemistry. These animals inherit as a Mendelian recessive trait an aganglionic distal colon. In the region proximal to the aganglionic segment, there is an extensive transitional or hypogangli...

journal_title：Neurochemistry international

authors： Bu'lock AJ,Vaillant C,Dockray GJ

更新日期：1984-01-01 00:00:00

abstract：:On the basis of the specific [(3)H]quinuclidinyl-benzilate binding, the transport of muscarinic cholinergic receptors has been demonstrated in the ventral horn, sciatic nerve and in the 3 mm segments proximal and distal to the ligature of rat sciatic nerves ligated for 24 h (a) without electrolytic lesion, (b) six day...

journal_title：Neurochemistry international

authors： Gulya K,Kása P

更新日期：1984-01-01 00:00:00

abstract：:The effects of pretreatment of mice with some drugs which modify GABAergic neurotransmission on the convulsions and cerebellar cyclic nucelotide level changes induced by the subsequent intracerebroventricular administration of 4-isopropyl-2,6,7-trioxa-1-phosphabicyclo(2,2,2)octane-1-oxide (IPTBO) have been studied. Mu...

journal_title：Neurochemistry international

authors： Blenkinsop IS,Coult DB,Davies WE,Howells DJ

更新日期：1984-01-01 00:00:00

abstract：:The coenzyme functions of the B vitamins in intermediatry metabolism are well established; nevertheless, for none of them is it possible to determine precisely the connection between the biochemical lesions associated with deficiency and the neurological consequences. Although there is convincing evidence of a neurosp...

journal_title：Neurochemistry international

authors： Bender DA

更新日期：1984-01-01 00:00:00

abstract：:The effects of the GABA agonist, muscimol on [(3)H]flunitrazepam binding were examined in cerebellum and hippocampus regions proposed to contain different populations of benzodiazepine binding site subtypes. Quantitative analysis was made of the contribution of different components of [(3)H]flunitrazepam binding by ut...

journal_title：Neurochemistry international

authors： Mitchell R,Wilson L

更新日期：1984-01-01 00:00:00

abstract：:Neuroblastoma cells, cultivated on plastic dishes, in presence of 15 mM glucose resist very well to hypoxia. Cells incubated on plastic dishes, if left unshaken, showed a Pasteur effect at an oxygen concentration below 10%. Oxygen diffusion was the limiting factor in these plastic dishes since improved oxygen diffusio...

journal_title：Neurochemistry international

authors： Pauwels PJ,Opperdoes FR,Trouet A

更新日期：1984-01-01 00:00:00

abstract：:One- and two-dimensional electrophoresis patterns and distribution of major cytoskeletal proteins were studied in primary astrocytes with either flat-epitheloid or stellate appearance. No major differences in the electrophoretic patterns of actin, tubulin, glial fibrillary acidic protein (GFAP) and vimentin were detec...

journal_title：Neurochemistry international

authors： Ciesielski-Treska J,Ulrich G,Mensch C,Aunis D

更新日期：1984-01-01 00:00:00

abstract：:The release of [(3)H]GABA which is newly synthesized from [(3)H]l-glutamic acid (GLU) has been examined using striatal slices obtained from the rat brain. It was found that 8-10% of [(3)H]GLU transported was converted to [(3)H]GABA during the incubation of striatal slices in the presence of nipecotic acid (5 x 10(?5) ...

journal_title：Neurochemistry international

authors： Yoneda Y,Kanmori K,Takahashi M,Zuo PP,Paik IH,Kuriyama K

更新日期：1984-01-01 00:00:00

abstract：:Using immunohistochemical methods at the light and electron microscope level, the coexistence between a hypophysiotropic factor and an apparently unrelated neuropeptide was demonstrated in three distinct infundibular neuronal systems. The present results emphasize the importance of demonstrating peptide coexistences f...

journal_title：Neurochemistry international

authors： Tramu G,Beauvillain JC,Croix D,Pillez A,Garaud JC

更新日期：1984-01-01 00:00:00

abstract：:The saturable and specific high-affinity uptake of [(3)H]serotonin ([(3)H]5HT) (5 x 10(?8) M) was studied in slices from the hippocampus, parietal cortex, septum-preoptic area, and hypothalamus of male 2, 6, 12 and 24-32 month old C57BL/6N mice. Hippocampal [(3)H]5-HT uptake showed a significant biphasic relationship ...

journal_title：Neurochemistry international

authors： Azmitia E,Brennan MJ,Quartermain D

更新日期：1983-01-01 00:00:00

abstract：:Tyrosine hydroxylase (TH) was purified from bovine brain and enzymatically phosphorylated in vitro. Radioactively phosphorylated TH was dephosphorylated by rat tissue extracts. Of tissues examined, rat corpus striatal extracts were highest in specific activity in the TH dephosphorylating assay. Phosphorylated histone ...

journal_title：Neurochemistry international

authors： Lazar MA,Raese JD,Barchas JD

更新日期：1983-01-01 00:00:00

abstract：:Various populations of bovine adrenal chromaffin cells were isolated first by successive digestions with collagenase (original cell preparation) followed by sedimentation through a stepwise bovine serum albumin gradient (cell layers I, II and III). At the fine structural level, the ratios between the number of adrenal...

journal_title：Neurochemistry international

authors： Lemaire S,Dumont M,Mercier P,Lemaire I,Calvert R

更新日期：1983-01-01 00:00:00

abstract：:A biochemical study of the endogenous levels of serotonin (5-HT), noradrenaline (NA) and the activity of choline acetyltransferase (CAT) was carried out in the intestinal tract of the rat. High levels of 5-HT and NA were detected in the caecum and the colon. These anatomical regions also presented the highest activity...

journal_title：Neurochemistry international

authors： Legay C,Faudon M,Ternaux JP

更新日期：1983-01-01 00:00:00

abstract：:Recent in vitro studies have revealed that benzodiazepines, opiates, barbiturates and ethanol might influence GABA binding to CNS membrane sites. Further studies of such interactions might be helpful for explaining both the mechanisms of action of these psychoactive agents and the tolerance/dependence that might resul...

journal_title：Neurochemistry international

authors： Defeudis FV

更新日期：1983-01-01 00:00:00

abstract：:Tissue preparations from the brain of rats and guinea-pigs were examined for their activity in binding isotopically labelled colchicine, as a measure of their content of tubulin. The amount of binding material extracted into a cold buffered solution was unaffected by keeping tissues at 0 degrees C. It diminished by on...

journal_title：Neurochemistry international

authors： McIlwain H,Poll JD

更新日期：1983-01-01 00:00:00

abstract：:The developmental profile of cytosolic sialidase from the nerve ending and the nerve ending-free compartments of rat forebrain was studied from birth to 150 days. Soluble extracts containing the cytosol from nerve endings and nerve ending-free tissue were separately prepared; the recovery of cytosol in the two extract...

journal_title：Neurochemistry international

authors： Venerando B,Fiorilli A,Malesci A,Goi GC,Lombardo A,Preti A,Tettamanti G

更新日期：1983-01-01 00:00:00

abstract：:Purified synaptic vesicles were isolated from hog cerebral cortex by a rapid procedure consisting of homogenization of cerebral cortex slices in iso-osmotic sucrose, differential centrifugation and sucrose density-gradient centrifugation. The purity of the vesicles was evaluated both biochemically and morphologically....

journal_title：Neurochemistry international

authors： Angel I,Fleissner A,Seifert R

更新日期：1983-01-01 00:00:00

abstract：:In the past few years, several studies have demonstrated in the rat subcommissural organ the presence of nerve endings and modified ependymocytes showing an uptake of [(3)H]GABA. The present work was performed to demonstrate in this cerebral zone the possibility of a GABA synthesis by the immunohistochemical localizat...

journal_title：Neurochemistry international

authors： Weissmann-Nanopoulos D,Belin MF,Didier M,Aguera M,Partisani M,Maitre M,Pujol JF

更新日期：1983-01-01 00:00:00

abstract：:Cholinergic neuroblastoma NS20Y cells were differentiated by the chicken gizzard extract. They were first inoculated into a glass culture bottle and the aggregated cells which grew in the suspension culture were collected. The aggregated cells (round and immature neuroblastoma cells) were seeded on a polyornithinecoat...

journal_title：Neurochemistry international

authors： Miki N,Higashida H,Hayashi Y,Akiyama M,Kuo CH

更新日期：1982-01-01 00:00:00

abstract：:Guanylate cyclase in the membrane fraction of rod outer segments (ROS-membrane) from the frog retina showed an extremely high activity but had no responsiveness to NaN(3) (+catalase), nitrosoguanidine or superoxide dismutase. These compounds, however, markedly activated the enzyme in a soluble fraction from the retina...

journal_title：Neurochemistry international

authors： Yoshikawa K,Nishimura C,Kuriyama K

更新日期：1982-01-01 00:00:00

abstract：:NaIO(4) oxidation, exo- and endo-glycosidase treatments and combinations thereof have been applied to acetylcholine receptor from Torpedo marmorata in its membrane-bound and detergent-solubilised forms. The effects of these chemical and enzymatic treatments are made apparent in the electrophoretic properties of the fo...

journal_title：Neurochemistry international

authors： Criado M,Barrantes FJ

更新日期：1982-01-01 00:00:00

abstract：:The short-term influences of stress on the activities of tyrosine hydroxylase in vivo and in vitro were examined in mice. The in vivo tyrosine hydroxylase activity was estimated by the rate of dopa accumulation which was measured at 30 min after the injection of NSD-1015 (100 mg kg), an aromatic l-amino acid decarboxy...

journal_title：Neurochemistry international

authors： Oka K,Ashiba G,Kiss B,Nagatsu T

更新日期：1982-01-01 00:00:00

abstract：:The correlation between rotational behaviors and neurochemical changes associated with the striatal damage induced by an unilateral microinjection of kainic acid were investigated. Shortly after the unilateral striatal injection of kainic acid, rats exhibited contralateral rotational behaviors, and these changes were ...

journal_title：Neurochemistry international

authors： Kuriyama K,Kurihara E

更新日期：1982-01-01 00:00:00

abstract：:The neonatal administration of 5,7-dihydroxytryptamine to rats (100 mg kg(?1) s.c. on the 1st and 2nd day after birth) resulted in marked reductions in serotoninergic presynaptic markers ([(3)H]-5-HT synaptosomal uptake, tryptophan hydroxylase activity and endogenous 5-HT content) in various forebrain areas, particula...

journal_title：Neurochemistry international

authors： Hamon M,Nelson DL,Mallat M,Bourgoin S

更新日期：1981-03-01 00:00:00

abstract：:Guanylate cyclase (GTP pyrophosphate-lyase (cyclizing); EC 4.6.1.2), in the crude synaptosomal soluble (P(2)-soluble) fraction obtained by hypo-osmotic treatment and subsequent centrifugation of crude synaptosomal (P(2)) fraction from the rat brain, showed a significantly high activity when assayed in the presence of ...

journal_title：Neurochemistry international

authors： Yoshikawa K,Kuriyama K

更新日期：1981-01-01 00:00:00

abstract：:Nerve terminals from the head ganglia of Locusta migratoria were isolated by means of a modified microscale flotation technique. Enzymatic, ultrastructural and chemical analysis revealed that the synaptosomal fraction was highly enriched in well-preserved nerve endings containing almost no free mitochondria. Cholinerg...

journal_title：Neurochemistry international

authors： Breer H

更新日期：1981-01-01 00:00:00

abstract：:In order to compare the incorporation of several saturated fatty acids into the brain, radioactive palmitic, stearic and lignoceric acids were injected into mice. The radioactivity was measured in lipids from isolated neurons, astrocytes and myelin. Our data indicate that specific radioactivity of lignoceric acid afte...

journal_title：Neurochemistry international

authors： Morand O,Masson M,Baumann N,Bourre JM

更新日期：1981-01-01 00:00:00

abstract：:Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. They carbamylate the active catalytic site of the enzyme and the subsequent decarbamylation is a slow but measurable process. Similarly, acetylcholinesterase can be phosphonylated, and the dephosphonylation is extremely slow. Rapi...

journal_title：Neurochemistry international

authors： Dawson RM,Poretski M,Upsher CM

更新日期：1981-01-01 00:00:00

abstract：:Several metabolic transformations of vitamin A have now been found in the pigment epithelium of cattle retina, leading to the hypothesis that there may be a vitamin A cycle in these cells. A retinol binding protein of MW ? 17,000 in pigment epithelial cytosol has been identified independently in several laboratories. ...

journal_title：Neurochemistry international

authors： Berman ER,Segal N,Schneider A,Feeney L

更新日期：1980-01-01 00:00:00